Levels of soluble TREM‐1 in children with newly diagnosed type 1 diabetes and their siblings without type 1 diabetes: a Danish case–control study. Issue 8 (10th November 2016)

• Record Type: Journal Article
• Authors: Thorsen, Steffen U.; Pipper, Christian B.; Mortensen, Henrik B.; Skogstrand, Kristin; Pociot, Flemming; Johannesen, Jesper; Svensson, Jannet
• Is Part Of: Pediatric diabetes. Volume 18:Issue 8(2017)
• Page Start: 749
• Page End: 754
• Publication Date: 2016-11-10
• Subjects: Diabetes Mellitus -- Type 1 -- etiology -- human -- innate immunity -- sTREM‐1 protein -- TREM‐1 receptor; Diabetes in children -- Periodicals; 616.462
• DOI: 10.1111/pedi.12464
• Languages: English
• ISSNs: 1399-543X

Abstract

Abstract : Background: Type 1 diabetes (T1D) is an organ‐specific autoimmune disease with an increase in incidence worldwide including Denmark. The triggering receptor expressed on myeloid cells‐1 (TREM‐1) is a potent amplifier of pro‐inflammatory responses and has been linked to autoimmunity, severe psychiatric disorders, sepsis, and cancer. Hypothesis: Our primary hypothesis was that levels of soluble TREM‐1 (sTREM‐1) differed between newly diagnosed children with T1D and their siblings without T1D. Methods: Since 1996, the Danish Childhood Diabetes Register has collected data on all patients who have developed T1D before the age of 18 years. Four hundred and eighty‐one patients and 478 siblings with measurements of sTREM‐1—blood samples were taken within 3 months after onset—were available for statistical analyses. Sample period was from 1997 through 2005. A robust log‐normal regression model was used, which takes into account that measurements are left censored and accounts for correlation within siblings from the same family. Results: In the multiple regression model (case status, gender, age, HLA‐risk, season, and period of sampling), levels of sTREM‐1 were found to be significantly higher in patients (relative change [95%CI], 1.5 [1.1; 2.2], P = 0.02), but after adjustment for multiple testing our result was no longer statistically significant ( P adjust = 0.1). We observed a statistical significant temporal increase in levels of sTREM‐1. Conclusion: Our results need to be replicated by independent studies, but our study suggests that the TREM‐1 pathway may have a role in T1D pathogenesis.