Solvent‐Driven Iodine‐Mediated Oxidative Strategies for the Synthesis of Bis(imidazo[1, 2‐a]pyridin‐3‐yl)sulfanes and Disulfanes. Issue 23 (2nd November 2017)

• Record Type: Journal Article
• Authors: Shakoor, S. M. Abdul; Agarwal, Devesh S.; Khullar, Sadhika; Mandal, Sanjay K.; Sakhuja, Rajeev
• Is Part Of: Chemistry, an Asian journal. Volume 12:Issue 23(2017)
• Page Start: 3061
• Page End: 3068
• Publication Date: 2017-11-02
• Subjects: C−H activation -- iodine -- phenylimdazo[1, 2-a]pyridines -- sulfenylation; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/asia.201701274
• Languages: English
• ISSNs: 1861-4728

Abstract

Abstract: Two efficient iodine‐mediated strategies, which are economical and one‐pot, are described to access bis(imidazo[1, 2‐ a ]pyridin‐3‐yl)sulfanes and bis(imidazo[1, 2‐ a ]pyridin‐3‐yl)disulfanes in chloroform and acetic acid, respectively, by a direct oxidative homocoupling of imidazo‐heterocycles using inexpensive sodium sulfide as a sulfur source. These strategies are scalable, and an array of substrates delivered their corresponding stable sulfur‐bridged imidazo‐heterocycles in excellent yields. Abstract : Economical in 1‐pot : Two efficient iodine‐mediated strategies are described to access bis(imidazo[1, 2‐ a ]pyridin‐3‐yl)sulfanes and bis(imidazo[1, 2‐ a ]pyridin‐3‐yl)disulfanes in chloroform and acetic acid, respectively, by a direct oxidative homocoupling of imidazo‐heterocycles using inexpensive sodium sulfide as a sulfur source.