Activity Restriction Increases Deoxypyridinoline Excretion in Hospitalized High-Risk Pregnant Women. (January 2014)

• Record Type: Journal Article
• Authors: Vanderspank, Dana; Bernier, Suzanne M.; Sopper, Maggie M.; Watson, Patricia; Mottola, Michelle F.
• Other Names: Maloni Judith A. guest-editor.; Smith Barbara A. guest-editor.
• Is Part Of: Biological research for nursing. Volume 16:Number 1(2014:Jan.)
• Page Start: 7
• Page End: 15
• Publication Date: 2014-01
• Subjects: deoxypyridinoline -- high-risk pregnancy -- activity restriction -- bone metabolism; Clinical biochemistry -- Periodicals; Physiology, Pathological -- Periodicals; Nursing -- Periodicals; Nursing -- Research -- Periodicals; 610.73
• DOI: 10.1177/1099800412463120
• Languages: English
• ISSNs: 1099-8004

Abstract

Purpose: Activity restriction (AR), one of the most common interventions used in high-risk pregnancies, may exacerbate loss of bone mass. The purpose of this study was to determine changes over time in bone resorption in hospitalized AR women during late pregnancy. Methods: This was a short-term prospective study conducted in two tertiary-care obstetric hospitals. We measured urinary deoxypyridinoline (Dpd) excretion, a marker of bone resorption, once per week in a convenience sample of 14 hospitalized AR women in the third trimester and compared values at 28–31 and 34–36 weeks' gestation to those of 11 ambulatory control women. Both groups completed a bone-loading questionnaire, 3-day food intake record, and pedometer step counts at the same gestational age. Results: Urinary Dpd excretion increased from Days 1–7 (2.60 ± 0.32 nmol/mmol creatinine) to Days 22–28 (5.36 ± 0.83 nmol/mmol creatinine; p ≤ .05). Dpd excretion was higher in AR women (4.51 ± 0.31 nmol/mmol creatinine) than ambulatory women (2.72 ± 0.39 nmol/mmol creatinine) at 34–36 weeks' gestation ( p ≤ .05). Energy intake between ambulatory and AR women was not different ( p ≥ .05). All women met the daily requirements for calcium and vitamin D intake during pregnancy. Average daily pedometer steps for the AR women were significantly less compared to controls (1, 329 ± 936 and 8, 024 ± 1, 890 steps/day, respectively; p ≤ .05). Conclusions: AR leads to increased bone resorption in hospitalized pregnant women, which may impact future risk of developing osteopenia and osteoporosis.