Depression and anxiety in multiple system atrophy. (26th July 2017)

• Record Type: Journal Article
• Authors: Zhang, L.‐Y.; Cao, B.; Zou, Y.‐T.; Wei, Q.‐Q.; Ou, R.‐W.; Zhao, B.; Wu, Y.; Shang, H.‐F.
• Is Part Of: Acta neurologica Scandinavica. Volume 137:Number 1(2018)
• Page Start: 33
• Page End: 37
• Publication Date: 2017-07-26
• Subjects: anxiety -- depression -- multiple system atrophy; Neurology -- Periodicals; 616.8
• DOI: 10.1111/ane.12804
• Languages: English
• ISSNs: 0001-6314

Abstract

Abstract : Background: It has been noticed that the patients with multiple system atrophy (MSA) can accompany with depression and anxiety. This study aimed to establish the incidence and determinants of depression and anxiety symptoms in Chinese MSA patients. Methods: A total of 237 MSA patients were enrolled in the study. Neuropsychological assessment was performed using Hamilton Depression Rating Scale‐24 items and Hamilton Anxiety Rating Scale. Results: We found that 62.0% and 71.7% patients had at least mild depression and anxiety symptoms, respectively. The severity of depression of MSA patients was associated with lower educational years ( P =.024), longer disease duration ( P <.001), and disease severity ( P <.001). The severity of anxiety was associated with increased disease duration ( P <.001), disease severity ( P =.013), and orthostatic hypotension ( P =.005). Binary logistic regression showed the determinants of depression and anxiety were female gender, longer disease duration, and disease severity. Conclusion: Depression and anxiety symptoms are common in patients with MSA. Neurologists should pay attention to depression and anxiety in patients with MSA, especially in female patients and those with longer disease duration and severe disease condition.