Cypate‐mediated thermosensitive nanoliposome for tumor imaging and photothermal triggered drug release. Issue 12 (20th January 2017)

• Record Type: Journal Article
• Authors: Han, Zhihao; Lv, Liwei; Ma, Yi; Wang, Zhaohui; Liu, Yuxi; Zhang, Min; Li, Siwen; Gu, Yueqing
• Other Names: Luo Qingming guestEditor.
• Is Part Of: Journal of biophotonics. Volume 10:Issue 12(2017)
• Page Start: 1607
• Page End: 1616
• Publication Date: 2017-01-20
• Subjects: Cypate -- photothermal sensitive liposomes -- ERP effect -- Photothermal conversion -- photochemical internalization; Photonics -- Periodicals; Optical materials -- Periodicals; Optics -- Periodicals; Medical instruments and apparatus -- Periodicals; 621.3605
• DOI: 10.1002/jbio.201600270
• Languages: English
• ISSNs: 1864-063X

Abstract

Abstract : It is an emerging focus to explore controlled release drug delivery systems for simultaneous cancer imaging and therapy. Herein, we synthesized a photothermal sensitive multifunctional nano‐liposome drug delivery system, with doxorubicin wrapped in the hydropholic layer as the therapeutical agent and cypate doped in the hydrophobic layer as the diagnostic agent. A series of in vitro and in vivo characterization demonstrated the stability of synthesized liposome, as the DL% was 9 ± 1.5 and the EE% was 82.7 ± 2.1. And the liposome achieved the functions of target‐delivery, enhanced photochemical internalized drug release, and simultaneous chemotherapy and thermal therapy, indicating that this multifunctional nano‐liposome is a promising drug delivery system for tumor diagnosis and targeting therapy. Abstract : Nanoscale drug delivery systems are attracting considerable attention as an alternative strategy to overcome a lot of limitation. The multifunctional photothermal sensitive liposomes drug‐loading system was established, with cypate and DOX carried in it for multi‐mechanism diagnosis and treatment of tumor diseases. The attractive features of DOX@PTSL demonstrated here support the anticipation of its promising prospect in cancer therapy.