Comparing the Renal Safety of Isoosmolar Versus Low-Osmolar Contrast Medium by Renal Biomarkers N-Acetyl-β-d-Glucosaminidase and Endothelin. (February 2014)

• Record Type: Journal Article
• Authors: Semerci, Tuna; Çuhadar, Serap; Akçay, Filiz Akyıldız; Aydın, Tuğba Kantaroğlu; Atay, Ayşenur; Köseoğlu, Mehmet; Bayata, Serdar
• Is Part Of: Angiology. Volume 65:Number 2(2014)
• Page Start: 108
• Page End: 112
• Publication Date: 2014-02
• Subjects: contrast agents -- contrast-induced nephropathy -- coronary angiography -- endothelins; Blood-vessels -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; 616.13005
• DOI: 10.1177/0003319712469094
• Languages: English
• ISSNs: 0003-3197

Abstract

Iodixanol and iopamidol are commonly used contrast agents in coronary angiography. We evaluated the nephrotoxic effects of both contrast media in relation to renal biomarkers. A total of 38 low-risk patients who underwent coronary angiography were enrolled. Patients were randomized to receive either low-osmolar nonionic monomer or isoosmolar nonionic dimer contrast medium. N -Acetyl-β-d -glucosaminidase (NAG), endothelin, blood urea nitrogen, and urine and serum creatinine (SCr) levels were measured before the procedure (T0), at 6 hours (T6), and at 1 year after the procedure. Plasma endothelin, urine NAG/creatinine, and SCr were higher; accordingly, the urine creatinine values were lower in both the groups when comparing T0 versus T6. The groups were similar with each other when comparing T0 and T6 values. Both the contrast agents may be safely used at a low volume for coronary angiography in low-risk patients. Endothelin and NAG are sensitive to acute renal changes in function. There is a need for further prospective investigations with more patients.