Estrogen Receptor Activation Protects Against TNF-α-Induced Endothelial Dysfunction. (January 2014)
- Record Type:
- Journal Article
- Title:
- Estrogen Receptor Activation Protects Against TNF-α-Induced Endothelial Dysfunction. (January 2014)
- Main Title:
- Estrogen Receptor Activation Protects Against TNF-α-Induced Endothelial Dysfunction
- Authors:
- Palmieri, Daniela
Perego, Patrizia
Palombo, Domenico - Abstract:
- Lack of estrogen is a cause of cardiovascular disease in men and postmenopausal women. We examined the effects of estrogen receptor (ERs) activation/inactivation on endothelial cells subjected to tumor necrosis factor (TNF) α, which is involved in vascular disease pathogenesis. Endothelial nitric oxide synthase (eNOS) and matrix metalloproteinases (MMP) 9 expression, as well as protein kinase B (PKB) activation were evaluated as markers of endothelial dysfunction. The TNF-α induces eNOS and MMP-9 expression and PKB activation. The ER activation by apigenin, a nonsteroidal compound with estrogen-like activity mediated through ER binding-dependent pathways, counteracts these effects. These effects are reversed by classic (ER-α and ER-β) and nonclassic (G-protein-coupled receptor) ER inhibitors (ICI182 780 and pertussis toxin, respectively). Our data suggest that ER activation counteracts endothelial dysfunction induced by TNF-α. The use of ER activators, such as apigenin, may represent a strategy to prevent vascular disease associated with endothelial dysfunction, while avoiding the feminizing effects of estrogens.
- Is Part Of:
- Angiology. Volume 65:Number 1(2014)
- Journal:
- Angiology
- Issue:
- Volume 65:Number 1(2014)
- Issue Display:
- Volume 65, Issue 1 (2014)
- Year:
- 2014
- Volume:
- 65
- Issue:
- 1
- Issue Sort Value:
- 2014-0065-0001-0000
- Page Start:
- 17
- Page End:
- 21
- Publication Date:
- 2014-01
- Subjects:
- apigenin -- endothelial dysfunction -- eNOS -- estrogen receptor -- MMP-9 -- TNF-α
Blood-vessels -- Diseases -- Periodicals
Cardiovascular system -- Diseases -- Periodicals
616.13005 - Journal URLs:
- http://ang.sagepub.com ↗
http://firstsearch.oclc.org ↗
http://galenet.galegroup.com/servlet/HWRC?locID=lcml_main ↗
http://www.sagepublications.com/ ↗ - DOI:
- 10.1177/0003319713477909 ↗
- Languages:
- English
- ISSNs:
- 0003-3197
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 5432.xml