NT-ProBNP Independently Predicts Long-Term Mortality in Patients Admitted for Coronary Angiography. (January 2014)

• Record Type: Journal Article
• Authors: Ruwald, Martin Huth; Goetze, Jens Peter; Bech, Jan; Nielsen, Olav Wendelboe; Madsen, Bente Kühn; Nielsen, Lars Bo; Mouridsen, Mette; Ruwald, Anne-Christine Huth; Madsen, Jan Kyst; Pedersen, Sune
• Is Part Of: Angiology. Volume 65:Number 1(2014)
• Page Start: 31
• Page End: 36
• Publication Date: 2014-01
• Subjects: N-terminal pro-B-type natriuretic peptide -- biomarkers -- coronary artery disease -- heart failure; Blood-vessels -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; 616.13005
• DOI: 10.1177/0003319712462758
• Languages: English
• ISSNs: 0003-3197

Abstract

Recently, research interests are focussed on biomarkers to predict the outcome in patients with coronary artery disease (CAD). We examined whether the levels of N -terminal pro-B-type natriuretic peptide (NT-proBNP) could predict outcome in patients who underwent elective or acute coronary angiography (CAG). A total of 337 patients with suspected CAD who underwent elective or acute CAG were followed up for a mean period of 6.7 years. Primary end points were all-cause mortality (ACM) and the combined end point of ACM, nonfatal myocardial infarction, and revascularization. In all, 53 (16%) patients died and 88 (26%) patients reached the combined end point. Preprocedural NT-proBNP above 32 pmol/L independently predicted ACM (hazard ratio [HR] 3.11; confidence interval [CI]: 1.60-6.07; P = .001) and the combined end point (HR 2.44 [CI: 1.50-3.97]; P < .001). This study indicates that high NT-proBNP is an independent predictor of ACM on long-term follow-up. N -terminal-proBNP is a reliable predictive marker of mortality in the setting of stable or unstable angina.