A Case of Congenital Infantile Fibrosarcoma of the Bowel Presenting as a Neonatal Intussusception. Issue 12 (1st November 2017)

• Record Type: Journal Article
• Authors: Obayashi, Juma; Koizumi, Hirotaka; Hoshikawa, Masahiro; Wakisaka, Munechika; Fujikawa, Atsuko; Kitagawa, Hiroaki; Takagi, Masayuki
• Is Part Of: Pathology international. Volume 67:Issue 12(2017)
• Page Start: 644
• Page End: 648
• Publication Date: 2017-11-01
• Subjects: congenital infantile fibrosarcoma -- ETV6‐NTRK3 fusion -- ileocecal lesion -- intussusception -- neonate; Pathology -- Periodicals; 616.07
• DOI: 10.1111/pin.12603
• Languages: English
• ISSNs: 1320-5463

Abstract

Abstract : Neonatal intussusception of the intestinal tract is rare. However, most neonatal intussusceptions have an organic lead point. For the lead point to be a neoplasm is extremely rare. We report a case that presented with neonatal intussusception with a congenital infantile fibrosarcoma as the lead point. The detection of ETV6‐NTRK3 gene fusion was useful, although the definitive diagnosis was achieved by a comprehensive evaluation including this gene analysis, standard histology and immunohistochemistry. Neonatal intussusception should be suspected to be caused by a neoplasm. If pathological diagnosis is difficult, molecular analysis should be utilized to diagnose congenital infantile fibrosarcoma.