Differential standard deviation of log‐scale intensity based optical coherence tomography angiography. Issue 12 (30th January 2017)

• Record Type: Journal Article
• Authors: Shi, Weisong; Gao, Wanrong; Chen, Chaoliang; Yang, Victor X. D.
• Other Names: Luo Qingming guestEditor.
• Is Part Of: Journal of biophotonics. Volume 10:Issue 12(2017)
• Page Start: 1597
• Page End: 1606
• Publication Date: 2017-01-30
• Subjects: biomedical imaging -- optical coherence tomography angiography (OCTA) -- en face microvascular images -- SNR -- spatial resolution; Photonics -- Periodicals; Optical materials -- Periodicals; Optics -- Periodicals; Medical instruments and apparatus -- Periodicals; 621.3605
• DOI: 10.1002/jbio.201600264
• Languages: English
• ISSNs: 1864-063X

Abstract

Abstract : In this paper, a differential standard deviation of log‐scale intensity (DSDLI) based optical coherence tomography angiography (OCTA) is presented for calculating microvascular images of human skin. The DSDLI algorithm calculates the variance in difference images of two consecutive log‐scale intensity based structural images from the same position along depth direction to contrast blood flow. The en face microvascular images were then generated by calculating the standard deviation of the differential log‐scale intensities within the specific depth range, resulting in an improvement in spatial resolution and SNR in microvascular images compared to speckle variance OCT and power intensity differential method. The performance of DSDLI was testified by both phantom and in vivo experiments. In in vivo experiments, a self‐adaptive sub‐pixel image registration algorithm was performed to remove the bulk motion noise, where 2D Fourier transform was utilized to generate new images with spatial interval equal to half of the distance between two pixels in both fast‐scanning and depth directions. The SNRs of signals of flowing particles are improved by 7.3 dB and 6.8 dB on average in phantom and in vivo experiments, respectively, while the average spatial resolution of images of in vivo blood vessels is increased by 21%. Abstract : Differential standard deviation of log‐scale intensity (DSDLI) based optical coherence tomography angiography (OCTA) was presented to enhance the contrast of microvasculature maps. The signal noise ratio and the spatial resolution of blood vessels are both improved greatly with our method compared to speckle variance OCT and power intensity method, which suggests a promising application of DSDLI in the disease diagnosis and monitoring.