Design and 3D printing of a stainless steel reactor for continuous difluoromethylations using fluoroform. Issue 6 (15th November 2017)

• Record Type: Journal Article
• Authors: Gutmann, Bernhard; Köckinger, Manuel; Glotz, Gabriel; Ciaglia, Tania; Slama, Eyke; Zadravec, Matej; Pfanner, Stefan; Maier, Manuel C.; Gruber-Wölfler, Heidrun; Oliver Kappe, C.
• Is Part Of: Reaction chemistry & engineering. Volume 2:Issue 6(2017)
• Page Start: 919
• Page End: 927
• Publication Date: 2017-11-15
• Subjects: Reaction mechanisms (Chemistry) -- Periodicals; Chemical engineering -- Periodicals; Chemical engineering; Reaction mechanisms (Chemistry); Periodicals; 547.705
• DOI: 10.1039/c7re00176b
• Languages: English
• ISSNs: 2058-9883

Abstract

Abstract : The design and 3D printing of a stainless steel reactor for reaction with a gaseous reagent is described. Abstract : Herein we present a continuous flow reactor printed from stainless steel by selective laser melting. The reactor was specifically designed for a fast difluoromethylation reaction with n BuLi as base and fluoroform as atom-economic and inexpensive reagent. The reactor features four inlets to allow introduction of substrate, n BuLi, fluoroform, and a final quench solution. The reaction was completed within less than 2 min at −65 °C. The utilization of stainless steel as reactor material is critical to accomplish the heat transfer as well as the chemical and mechanical resistance that is required for this transformation.