Micromixing enables chemoselective reactions of difunctional electrophiles with functional aryllithiums. Issue 6 (16th October 2017)

• Record Type: Journal Article
• Authors: Nagaki, Aiichiro; Ishiuchi, Satoshi; Imai, Keita; Sasatsuki, Kengo; Nakahara, Yuichi; Yoshida, Jun-ichi
• Is Part Of: Reaction chemistry & engineering. Volume 2:Issue 6(2017)
• Page Start: 862
• Page End: 870
• Publication Date: 2017-10-16
• Subjects: Reaction mechanisms (Chemistry) -- Periodicals; Chemical engineering -- Periodicals; Chemical engineering; Reaction mechanisms (Chemistry); Periodicals; 547.705
• DOI: 10.1039/c7re00142h
• Languages: English
• ISSNs: 2058-9883

Abstract

Abstract : Generation of highly unstable functional aryllithiums followed by chemoselective reactions with difunctional electrophiles were successfully achieved using flow microreactor systems equipped with micromixers to give highly functionalized compounds without protecting functional groups. Abstract : Generation of highly unstable functional aryllithiums followed by chemoselective reactions with difunctional electrophiles were successfully achieved using flow microreactor systems equipped with micromixers to give highly functionalized compounds without protecting functional groups. Extremely fast micromixing is responsible for high chemoselectivity.