MTOR-sensitive translation: Cleared fog reveals more trees. Issue 10 (3rd October 2017)
- Record Type:
- Journal Article
- Title:
- MTOR-sensitive translation: Cleared fog reveals more trees. Issue 10 (3rd October 2017)
- Main Title:
- MTOR-sensitive translation: Cleared fog reveals more trees
- Authors:
- Masvidal, Laia
Hulea, Laura
Furic, Luc
Topisirovic, Ivan
Larsson, Ola - Abstract:
- ABSTRACT: Translation is fundamental for many biologic processes as it enables cells to rapidly respond to stimuli without requiring de novo mRNA synthesis. The mammalian/mechanistic target of rapamycin (mTOR) is a key regulator of translation. Although mTOR affects global protein synthesis, translation of a subset of mRNAs appears to be exceptionally sensitive to changes in mTOR activity. Recent efforts to catalog these mTOR-sensitive mRNAs resulted in conflicting results. Whereas ribosome-profiling almost exclusively identified 5′-terminal oligopyrimidine (TOP) mRNAs as mTOR-sensitive, polysome-profiling suggested that mTOR also regulates translation of non-TOP mRNAs. This inconsistency was explained by analytical and technical biases limiting the efficiency of ribosome-profiling in detecting mRNAs showing differential translation. Moreover, genome-wide characterization of 5′UTRs of non-TOP mTOR-sensitive mRNAs revealed 2 subsets of transcripts which differ in their requirement for translation initiation factors and biologic functions. We summarize these recent advances and their impact on the understanding of mTOR-sensitive translation.
- Is Part Of:
- RNA biology. Volume 14:Issue 10(2017)
- Journal:
- RNA biology
- Issue:
- Volume 14:Issue 10(2017)
- Issue Display:
- Volume 14, Issue 10 (2017)
- Year:
- 2017
- Volume:
- 14
- Issue:
- 10
- Issue Sort Value:
- 2017-0014-0010-0000
- Page Start:
- 1299
- Page End:
- 1305
- Publication Date:
- 2017-10-03
- Subjects:
- eIFs -- mRNA translation -- mTOR -- nanoCAGE -- polysome profiling -- ribosome profiling -- UTR
RNA -- Periodicals
Molecular biology -- Periodicals
Molecular biology
RNA
Periodicals
572.8805 - Journal URLs:
- http://www.tandfonline.com/loi/krnb ↗
http://www.landesbioscience.com/journals/rnabiology/ ↗
http://www.tandfonline.com/ ↗ - DOI:
- 10.1080/15476286.2017.1290041 ↗
- Languages:
- English
- ISSNs:
- 1547-6286
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 7993.991300
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 5418.xml