Pushing the photodelivery of nitric oxide to the visible: are {FeNO}7 complexes good candidates?. Issue 46 (9th November 2017)

• Record Type: Journal Article
• Authors: Levin, Natalia; Perdoménico, Julián; Bill, Eckhard; Weyhermüller, Thomas; Slep, Leonardo D.
• Is Part Of: Dalton transactions. Volume 46:Issue 46(2017)
• Page Start: 16058
• Page End: 16064
• Publication Date: 2017-11-09
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/c7dt03142d
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : The photoactivity displayed by the newly prepared [Fe((CH2 Py2 )2 Me[9]aneN3 )(NO)](BF4 )2 suggests that {FeNO} 7 octahedral coordination compounds may be employed for controlled NO-photorelease. Abstract : Photodelivery of NO requires stable compounds which can be made reactive by irradiation with (visible) light. Traditional {MNO} 6 complexes require a substantial ligand design to shift their absorption spectra to the appropriate region of the electromagnetic spectrum. [Fe((CH2 Py2 )2 Me[9]aneN3 )(NO)](BF4 )2 is a new {FeNO} 7 octahedral coordination compound, which is thermally and air-stable in solution. Illumination with a 450 nm light source induces significant photodetachment of the coordinated NO ( ϕ NO = 0.52 mol einstein −1 ), suggesting that {FeNO} 7 compounds can be in fact suitable compounds for therapeutic NO-photorelease.