Aptamer-modified selenium nanoparticles for dark-field microscopy imaging of nucleolin. Issue 97 (22nd November 2017)

• Record Type: Journal Article
• Authors: Liu, Meng Li; Zou, Hong Yan; Li, Chun Mei; Li, Rong Sheng; Huang, Cheng Zhi
• Is Part Of: Chemical communications. Volume 53:Issue 97(2017)
• Page Start: 13047
• Page End: 13050
• Publication Date: 2017-11-22
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc07664a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Selenium nanoparticles with good water solubility and excellent biocompatibility are used for the first time as a light-scattering nanoprobe with aptamer modification to image nucleolin-overexpressing cancer cells through dark-field microscopy. Abstract : Selenium nanoparticles (SeNPs) with strong green scattering light serving as light scattering nanoprobes for dark-field microscopy imaging are developed for the first time. The SeNPs show good stability, excellent biocompatibility, and high light-producing power, and can precisely and specifically target cancer cells with overexpressed nucleolin (NCL) after modification with aptamers, revealing that the SeNPs can act as a good light scattering nanoprobe for bioimaging and biolabeling.