An etching based fluorescent probe for sensitive detection of hydrogen sulfide in cells. Issue 24 (23rd November 2017)

• Record Type: Journal Article
• Authors: Dong, Yali; Wang, Ling; Wang, Feng; Li, Nan; Jin, Yi; Zhang, Jinchao; Yang, Xinjian
• Is Part Of: Analyst. Volume 142:Issue 24(2017)
• Page Start: 4703
• Page End: 4707
• Publication Date: 2017-11-23
• Subjects: Chemistry, Analytic -- Periodicals; 543
• DOI: 10.1039/c7an01394a
• Languages: English
• ISSNs: 0003-2654

Abstract

Abstract : A fluorescent nanoprobe is designed for sensitive detection of hydrogen sulfide in living cells based on surface etching and displacement. Abstract : Hydrogen sulfide (H2 S) is one of the most crucial gas signaling agents that mediate many physiological and pathological processes. However, rapid high-efficiency detection and imaging of H2 S in living cells is very challenging. Herein we reported a simple fluorescent nanoprobe using FAM-DNA/AgNP nanocomposites for fast and sensitive H2 S detection based on surface silver displacement. In contrast to the conventional principles for fluorescence turn-on analyte detection, the present work demonstrated a sensitive and selective AgNP based optosensor for the assay of H2 S. Compared with the majority of the reported H2 S probes, complex synthesis procedures and costly equipment are not involved in this assay.