Emerging therapies for pre-RA. Issue 1 (February 2017)

• Record Type: Journal Article
• Authors: Cope, Andrew P.
• Is Part Of: Best practice & research. Volume 31:Issue 1(2017:Feb.)
• Page Start: 99
• Page End: 111
• Publication Date: 2017-02
• Subjects: At risk -- Risk stratification -- RA prevention -- Arthralgia -- ACPA; Rheumatology -- Periodicals; Rheumatic Diseases -- Periodicals; Reumatologie; 616.723005
• DOI: 10.1016/j.berh.2017.08.005
• Languages: English
• ISSNs: 1521-6942

Abstract

Abstract: The field of rheumatology has made major contributions to medicine through the identification of cellular and molecular targets and the development of therapies for the treatment of an impressive range of immune-mediated inflammatory diseases such as rheumatoid arthritis. In recent years, new milestones have been achieved. These include the recognition of an at-risk state, characterized by disease specific autoantibodies in serum and inflammatory joint pain, and the initiation of studies seeking to prevent high-risk individuals from progressing to a state of clinically apparent arthritis. Here, the current state of the art of rheumatoid arthritis prevention is described, highlighting the importance of risk stratification and reporting on a growing portfolio of therapeutic interventions targeting different stages of the preclinical syndrome.