Current and future antenatal management of isolated congenital diaphragmatic hernia. Issue 6 (December 2017)

• Record Type: Journal Article
• Authors: Russo, Francesca Maria; De Coppi, Paolo; Allegaert, Karel; Toelen, Jaan; van der Veeken, Lennart; Attilakos, George; Eastwood, Mary Patrice; David, Anna Louise; Deprest, Jan
• Is Part Of: Seminars in fetal & neonatal medicine. Volume 22:Issue 6(2017)
• Page Start: 383
• Page End: 390
• Publication Date: 2017-12
• Subjects: Congenital diaphragmatic hernia -- Prenatal therapy -- Pulmonary hypoplasia -- Pulmonary hypertension -- Sildenafil; Neonatology -- Periodicals; Newborn infants -- Diseases -- Periodicals; Fetus -- Diseases -- Periodicals; 618.9201
• DOI: 10.1016/j.siny.2017.11.002
• Languages: English
• ISSNs: 1744-165X

Abstract

Abstract: Congenital diaphragmatic hernia is surgically correctable, yet the poor lung development determines mortality and morbidity. In isolated cases the outcome may be predicted prenatally by medical imaging. Cases with a poor prognosis could be treated before birth. However, prenatal modulation of lung development remains experimental. Fetoscopic endoluminal tracheal occlusion triggers lung growth and is currently being evaluated in a global clinical trial. Prenatal transplacental sildenafil administration may in due course be a therapeutic approach, reducing the occurrence of persistent pulmonary hypertension, either alone or in combination with fetal surgery.