Plasma big endothelin-1 and stent thrombosis: An observational study in patients undergoing percutaneous coronary intervention in China. Issue 159 (November 2017)

• Record Type: Journal Article
• Authors: Chen, Yan; Li, Jian-xin; Song, Ying; Xu, Jing-jing; Tang, Xiao-fang; Jiang, Lin; Jiang, Ping; Liu, Ru; Wang, Huan-huan; Zhao, Xue-yan; Chen, Jue; Gao, Zhan; Qiao, Shu-bin; Gao, Run-lin; Yang, Yue-jin; Xu, Bo; Yuan, Jin-qing
• Is Part Of: Thrombosis research. Issue 159(2017)
• Page Start: 5
• Page End: 12
• Publication Date: 2017-11
• Subjects: ST stent thrombosis -- PCI percutaneous coronary intervention -- CAD coronary artery disease -- ACS acute coronary syndrome -- ET-1 endothelin-1 -- ULN upper limit of normal -- DAPT dual antiplatelet therapy -- DES drug-eluting stent -- HR hazard ratio -- CI confidence interval -- NRI net reclassification improvement; Endothelin-1 -- Percutaneous coronary intervention -- Stent thrombosis -- Biomarker; Thrombosis -- Periodicals; 616.135
• DOI: 10.1016/j.thromres.2017.09.013
• Languages: English
• ISSNs: 0049-3848

Abstract

Abstract: Introduction: Stent thrombosis (ST) is a rare but catastrophic complication of percutaneous coronary intervention, leading to poor prognosis. Endothelin-1 (ET-1) plays an important role in endothelial dysfunction and thrombogenesis. However, the impact of big ET-1 level on ST in patients with coronary stenting is unknown. We aimed to evaluate big ET-1 level as a potential predictor of ST in patients undergoing percutaneous coronary intervention. Materials and methods: From January 2013 to December 2013, 8106 consecutive patients underwent successful coronary stent implantation and were prospectively enrolled in this study. Patients were stratified into three groups based on plasma big ET-1 level at admission. Results: The incidence of definite and probable ST at 2 years postoperatively was 0.84%; ST incidence was lowest in the low big ET-1 group (0.56%), highest in the high big ET-1 group (1.48%), and intermediate in the medium big ET-1 group (0.74%, log-rank p = 0.001). Compared with the low big ET-1 group, the multivariate-adjusted hazard ratio (HR) for ST in the high big ET-1 group was 2.06 (95% confidence interval (CI) 1.14–3.73, p = 0.017). In subgroup analyses, high big ET-1 level was independently associated with ST in patients with acute coronary syndrome (HR 2.29, 95% CI 1.03–5.06, p = 0.041), but not in those with stable coronary artery disease ( p = 0.331), and tended to be associated with older age. Conclusions: Plasma big ET-1 level is a valuable independent predictor of ST in patients with coronary stents, especially in the acute coronary syndrome population. Highlights: High plasma big ET-1 level is related with increased risk of stent thrombosis. Big ET-1 predicts ST in patients with acute coronary syndrome. It is the first study to assess the clinical impact of plasma big ET-1 level on ST. Blockade of ET-1 function to mitigate ST in special patients needs assessment.