The interaction of wood nanocellulose dressings and the wound pathogen P. aeruginosa. (10th February 2017)

• Record Type: Journal Article
• Authors: Jack, Alison A.; Nordli, Henriette R.; Powell, Lydia C.; Powell, Kate A.; Kishnani, Himanshu; Johnsen, Per Olav; Pukstad, Brita; Thomas, David W.; Chinga-Carrasco, Gary; Hill, Katja E.
• Is Part Of: Carbohydrate polymers. Volume 157(2017)
• Page Start: 1955
• Page End: 1962
• Publication Date: 2017-02-10
• Subjects: Nanocellulose -- Biofilms -- Pseudomonas aeruginosa -- COMSTAT -- Characterisation; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2016.11.080
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: CNF hydrogels indicated dose-dependent inhibition of P. aeruginosa . CNF wound dressing does not increase the virulence factors production by P. aeruginosa . The biofilm growth is affected by the surface and bulk structure of the assessed CNF dressings. Abstract: Chronic wounds pose an increasingly significant worldwide economic burden (over £1 billion per annum in the UK alone). With the escalation in global obesity and diabetes, chronic wounds will increasingly be a significant cause of morbidity and mortality. Cellulose nanofibrils (CNF) are highly versatile and can be tailored with specific physical properties to produce an assortment of three-dimensional structures (hydrogels, aerogels or films), for subsequent utilization as wound dressing materials. Growth curves using CNF (diameter <20 nm) in suspension demonstrated an interesting dose-dependent inhibition of bacterial growth. In addition, analysis of biofilm formation ( Pseudomonas aeruginosa PAO1) on nanocellulose aerogels (20 g/m 2 ) revealed significantly less biofilm biomass with decreasing aerogel porosity and surface roughness. Importantly, virulence factor production by P. aeruginosa in the presence of nanocellulose materials, quantified for the first time, was unaffected (p > 0.05) over 24 h. These data demonstrate the potential of nanocellulose materials in the development of novel dressings that may afford significant clinical potential.