Levels of interleukin (IL)‐6 and IL‐8 are elevated in serum and bronchoalveolar lavage fluid of haematological patients with invasive pulmonary aspergillosis. Issue 12 (6th September 2017)

• Record Type: Journal Article
• Authors: Heldt, Sven; Eigl, Susanne; Prattes, Juergen; Flick, Holger; Rabensteiner, Jasmin; Prüller, Florian; Niedrist, Tobias; Neumeister, Peter; Wölfler, Albert; Strohmaier, Heimo; Krause, Robert; Hoenigl, Martin
• Is Part Of: Mycoses. Volume 60:Issue 12(2017)
• Page Start: 818
• Page End: 825
• Publication Date: 2017-09-06
• Subjects: Aspergillus -- BAL -- haematological malignancy -- IFN‐γ -- IL‐10 -- IL‐17A -- serum; Pathogenic fungi -- Periodicals; Medical mycology -- Periodicals; 616.969
• DOI: 10.1111/myc.12679
• Languages: English
• ISSNs: 0933-7407

Abstract

Summary: Aspergillus spp. have been shown to induce T‐helper cell (Th) 1 and Th17 subsets resulting in elevated levels of several cytokines. The objective of this study was to analyse a bundle of cytokines in serum and bronchoalveolar lavage fluid (BALF) in patients with and without invasive pulmonary aspergillosis (IPA). This nested case‐control analysis included 10 patients with probable/proven IPA and 20 matched controls without evidence of IPA, out of a pool of prospectively enrolled (2014‐2017) adult cases with underlying haematological malignancies and suspected pulmonary infection. Serum samples were collected within 24 hours of BALF sampling. All samples were stored at −70°C for retrospective determination of cytokines. IL‐6 and IL‐8 were significantly associated with IPA in both serum ( P = .011 and P = .028) and BALF ( P = .006 and P = .012, respectively), and a trend was observed for serum IL‐10 ( P = .059). In multivariate conditional logistic regression analysis, IL‐10 remained a significant predictor of IPA in serum and IL‐8 among BALF cytokines. In conclusion, levels of IL‐6 and IL‐8 were significantly associated with probable/proven IPA, and a similar trend was observed for serum IL‐10. Future cohort studies should determine the diagnostic potential of these cytokines for IPA, and evaluate combinations with other IPA biomarkers/diagnostic tests.