Lanthanide DO3A‐Tropone Complexes: Efficient Dual MR/NIR Imaging Probes in Aqueous Medium. Issue 43 (14th September 2017)

• Record Type: Journal Article
• Authors: Hashami, Zohreh; Martins, Andre F.; Funk, Alexander M.; Jordan, Veronica Clavijo; Petoud, Stéphane; Eliseeva, Svetlana V.; Kovacs, Zoltan
• Is Part Of: European journal of inorganic chemistry. Issue 43(2017)
• Page Start: 4965
• Page End: 4968
• Publication Date: 2017-09-14
• Subjects: Lanthanides -- Fluorescent probes -- Luminescence -- Tropones -- Imaging agents; Chemistry, Inorganic -- Periodicals; Organometallic chemistry -- Periodicals; Bioinorganic chemistry -- Periodicals; Solid state chemistry -- Periodicals; 546
• DOI: 10.1002/ejic.201701003
• Languages: English
• ISSNs: 1434-1948

Abstract

Abstract : In this work, we describe a novel DOTA (1, 4, 7, 10‐tetraazacyclododecane‐1, 4, 7, 10‐tetraacetic acid) based ligand with a chromophoric tropone coordinating sidearm (ligand1 ). Ln 3+ complexes of1 have one inner‐sphere water molecule. The r 1 relaxivity of Gd1 is similar to that of the commercial Gd‐based MRI agents. The neutral O ‐donor atom of the tropone moiety slows down the water exchange by a factor of 3 compared to that for GdDOTA. In addition, complexes Nd1 and Yb1 exhibit significant NIR emission in aqueous solutions, which indicates that the tropone unit is an efficient sensitizer for these Ln 3+ ions. Therefore, this new ligand is a promising platform for the design of Ln 3+ ‐based dual MR/optical imaging probes. Abstract : A DOTA derivative with a tropone coordinating sidearm forms monohydrated lanthanide complexes. The Gd 3+ ‐chelate has the expected relaxivity while the Nd 3+ and Yb 3+ complexes exhibit bright NIR luminescence despite the quenching effect of the inner‐sphere water molecule.