DNA interaction and cleavage studies of ancillary chiral ligand and N, N‐donor ligands coordinated platinum(II) complexes. (16th May 2017)

• Record Type: Journal Article
• Authors: Rajesh, Jegathalaprathaban; Kesavan, Mookkandi Palsamy; Ayyanaar, Srinivasan; Karthikeyan, Kesavan; Rajagopal, Gurusamy; Athappan, Periyakaruppan
• Is Part Of: Applied organometallic chemistry. Volume 31:Number 12(2017:Dec.)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-05-16
• Subjects: ancillary chiral ligand -- CD spectral studies -- dppz -- hyperchromic -- Pt(II) complexes; Organometallic chemistry -- Periodicals; Organometallic compounds -- Periodicals; 547.05
• DOI: 10.1002/aoc.3868
• Languages: English
• ISSNs: 0268-2605

Abstract

Abstract : Four new platinum(II) complexes [Pt(dpen)(bpy)](ClO4 )2 (1 ), [Pt(dpen)(phen)](ClO4 )2 (2 ), [Pt(dpen)(dpq)](ClO4 )2 (3 ) and [Pt(dpen)(dppz)](ClO4 )2 (4 ) comprising of different N, N‐donor ligands, viz., 2, 2′‐bipyridine (bpy), 1, l0‐phenanthroline (phen), dipyridoquinoxaline (dpq), dipyrido‐[3, 2‐d:2¢, 3¢‐ f –phenazine] (dppz), and chiral ancillary ligand 1R, 2R ‐1, 2‐diphenylethylenediamine (dpen) have been synthesized and characterized. The interaction of these complexes1–4 with calf‐thymus DNA (CT‐DNA) has been explored using absorption, circular dichroism spectral and cyclic voltammetric studies. The absorption spectrum of complex4 with dppz ligand exhibits a major red shift with an overall hypochromic as well as a hyperchromic effect in the presence of DNA, other complexes (1 –3 ) show only hypochromism. From these absorption spectral studies, the intercalative ability of the complexes follows the order as, 4 > 3 > 2 > 1, which is further confirmed by CD and cyclic voltammetry measurements. CD spectral studies show that DNA becomes more A ‐like upon interaction with the complexes1 &2 but the complexes3 &4 bring about B ‐form to Z ‐ form DNA conformational transition. The DNA cleavage study of these Pt(II) complexes1–4 carried out by gel electrophoresis revealed that complexes1–4 can cleave super coiled (SC) pUC18 DNA efficiently into open circular form (form II) under hydrolytic and oxidative conditions. Abstract : New Pt(II) complexes 1‐4 are prepared and characterized using spectral techniques. Complex 4 with dppz ligand and has effective DNA binding behavior than others. Pt(II) complexes 1‐4 cleaved super coiled DNA under hydrolytic as well as oxidative conditions.