From dendritic cells to B cells dysfunctions during HIV‐1 infection: T follicular helper cells at the crossroads. Issue 2 (27th March 2017)

• Record Type: Journal Article
• Authors: Ruffin, Nicolas; Hani, Lylia; Seddiki, Nabila
• Is Part Of: Immunology. Volume 151:Issue 2(2017)
• Page Start: 137
• Page End: 145
• Publication Date: 2017-03-27
• Subjects: dendritic cells -- germinal centre -- HIV‐1 -- SAM domain and HD domain‐containing protein 1 -- T follicular helper cell; Immunology -- Periodicals
• DOI: 10.1111/imm.12730
• Languages: English
• ISSNs: 0019-2805

Abstract

Summary: T follicular helper (Tfh) cells are essential for B‐cell differentiation and the subsequent antibody responses. Their numbers and functions are altered during human and simian immunodeficiency virus (HIV/SIV) infections. In lymphoid tissues, Tfh cells are present in germinal centre, where they are the main source of replicative HIV‐1 and represent a major reservoir. Paradoxically, Tfh cell numbers are increased in chronically infected individuals. Understanding the fate of Tfh cells in the course of HIV‐1 infection is essential for the design of efficient strategies toward a protective HIV vaccine or a cure. The purpose of this review is to summarize the recent advance in our understanding of Tfh cell dynamics during HIV/SIV infection. In particular, to explore the possible causes of their expansion in lymphoid tissues by discussing the impact of HIV‐1 infection on dendritic cells, to identify the molecular players rendering Tfh cells highly susceptible to HIV‐1 infection, and to consider the contribution of regulatory follicular T cells in shaping Tfh cell functions. Abstract : Molecular players rendering T follicular helper cells highly susceptible to HIV‐1 infection and being at the crossroads between innate and adaptive responses.