Toward understanding of the mechanisms of Mediator function in vivo: Focus on the preinitiation complex assembly. Issue 5 (20th October 2017)

• Record Type: Journal Article
• Authors: Eychenne, Thomas; Werner, Michel; Soutourina, Julie
• Is Part Of: Transcription. Volume 8:Issue 5(2017)
• Page Start: 328
• Page End: 342
• Publication Date: 2017-10-20
• Subjects: coactivator -- eukaryotic transcription -- functional genomics -- genetics -- human -- Mediator -- preinitiation complex -- RNA polymerase II -- structural biology -- yeast Saccharomyces cerevisiae; Genetic transcription -- Periodicals; 572.8
• DOI: 10.1080/21541264.2017.1329000
• Languages: English
• ISSNs: 2154-1264

Abstract

ABSTRACT: Mediator is a multisubunit complex conserved in eukaryotes that plays an essential coregulator role in RNA polymerase (Pol) II transcription. Despite intensive studies of the Mediator complex, the molecular mechanisms of its function in vivo remain to be fully defined. In this review, we will discuss the different aspects of Mediator function starting with its interactions with specific transcription factors, its recruitment to chromatin and how, as a coregulator, it contributes to the assembly of transcription machinery components within the preinitiation complex (PIC) in vivo and beyond the PIC formation.