Sensitive Potentiometric Determination of Amphetamine with an All-Solid-State Micro Ion-Selective Electrode. (11th February 2018)

• Record Type: Journal Article
• Authors: Gallardo-González, J.; Baraket, A.; Bonhomme, A.; Zine, N.; Sigaud, M.; Bausells, J.; Errachid, A.
• Is Part Of: Analytical letters. Volume 51:Number 3(2018)
• Page Start: 348
• Page End: 358
• Publication Date: 2018-02-11
• Subjects: Amphetamine -- cyclic voltammetry (CV) -- electrochemical impedance spectroscopy (EIS) -- micro ion-selective electrode (µISE); Chemistry, Analytic -- Periodicals; Chemistry, Analytic -- Abstracts; 543
• DOI: 10.1080/00032719.2017.1326053
• Languages: English
• ISSNs: 0003-2719

Abstract

ABSTRACT: The development of amphetamine-ion-selective microelectrodes using electrochemical polymerization and microfabrication technologies is reported in this study. The microelectrodes include polypyrrole films electrochemically polymerized and doped with cosane anion ([3, 3′-Co(1, 2-C2 B9 H11 )2 ] − ) as the internal solid contact layer between the polymeric sensitive membrane and platinum working microelectrode. Several poly(vinyl chloride)-type membranes with different compositions of plasticizers/ionophore were drop casted on the conducting polymer layer, polypyrrole[3, 3′-Co(1, 2-C2 B9 H11 )2 ]. Potentiometric measurements were performed to calibrate the response of the developed chemical sensors. The sensor was highly sensitive to amphetamine using a membrane composition of 26 wt% poly (vinyl chloride), 63 wt% di-butyl phthalate, 6 wt% sodium tetraphenylborate, and 5 wt% dibenzo-18-crown 6-ether. A high and linear response was demonstrated within the concentration range from 10 −5 to 10 −3 M with a slope of 53 mV/decade and a limit of detection of 4 × 10 −5 M. A Reilley diagram shows that the sensor signal is stable for a working pH between 1.50 and 8.50. The chemical sensor was highly selective to amphetamine when compared to other interfering ions and compounds including K +, Na +, , D, L -phenylalanine, caffeine, (±)-epinephrine bitartrate salt, and N -formylamphetamine using the fixed interference method with coefficients of selectivity (Log ) from −1.40 to −1.15.