Chemical constituents from the leaves of Pinus dalatensis Ferré. Issue 3 (1st February 2018)

• Record Type: Journal Article
• Authors: Sa, Nguyen Hoang; Tam, Nguyen Thanh; Anh, Nguyen Thi Hoang; Quan, Tran Duc; Thien, Dao Duc; Phong, Dinh Thi; Sung, Tran Van; Thuy, Trinh Thi
• Is Part Of: Natural product research. Volume 32:Issue 3(2018)
• Page Start: 341
• Page End: 345
• Publication Date: 2018-02-01
• Subjects: Pinus dalatensis Ferré -- labdane -- caryolane -- pinusolidic acid; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1350672
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A phytochemical study of n -hexane and ethyl acetate extracts of Pinus dalatensis Ferré leaves led to the isolation of 11 compounds, including one caryolane sesquiterpenoid (1 ), five labdane diterpenoids (2, 3, 4, 5, 6 ), one serratane triterpenoid (7 ), one diacylated flavonoid glucoside (8 ), one stilbenoid (9 ) and two sterols (10, 11 ). The structural characterisation of the isolated compounds was elucidated by spectroscopic data and comparison with the literature report on the chemical constituents from Pinus dalatensis Ferré. Futhermore, three compounds1, 4 and6 were obtained for the first time from the genus Pinus . Besides, compounds (2, 3, 5, 8, 9 ) were also subjected to cytotoxicity effect on SK-LU-1, MCF-7 and Hep-G2 cell lines, but only compound9 expressed activities with IC50 values of 141.22, 127.81 and 166.84 μM, respectively. Abstract :