Poly(propylene)-based Films Modified with a Tetracationic Phthalocyanine with Applications in Photodynamic Inactivation of Candida albicans. Issue 3 (11th February 2018) - Tempesti, Tomas
ABSTRACT: Photoactive films based on polymer-like poly(propylene) were generated and utilized as support of zinc(II)tetramethyltetrapyridino[2, 3- b :2′, 3′- g :2″, 3″- l :2″′, 3″′- q ]porphyrazinium salt (ZnTM2, 3PyPz). Using a photograft polymerization of acrylic acid, the poly(propylene) film was functionalized with carboxyl groups (PP- g -PAAc), which attached ZnTM2, 3PyPz by electrostatic bond to form PP- g -PAAc-Pc films. In vitro investigations indicated that PP- g -PAAc-Pc films produced photodynamic inactivation of Candida albicans cells, mainly mediated by a contribution of type II process. According to the results, the photodynamic activity produced by the PP- g -PAAc-Pc film and visible light irradiation can successfully inactivate C. albicans deposited on the surface of the films. GRAPHICAL ABSTRACT: