A new furofuran lignan from Piper terminaliflorum Tseng. Issue 3 (1st February 2018)

• Record Type: Journal Article
• Authors: Liu, Tie; Liang, Qian; Zhang, Xin-Min; Huang, Shen-Yang; Xu, Wen-Hui
• Is Part Of: Natural product research. Volume 32:Issue 3(2018)
• Page Start: 335
• Page End: 340
• Publication Date: 2018-02-01
• Subjects: Piper terminaliflorum Tseng -- furofuran lignan -- amide alkaloid -- cytotoxic activities; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1350671
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The chemical investigation of whole plants Piper terminaliflorum Tseng led to the isolation of one new furofuran lignan, 7-methoxyasarinin (1 ), along with three known amide alkaloids (2 –4 ) as N -3, 5-dimethoxy-4-hydroxycinnamoylpyrrole (2 ), dihydropipercide (3 ) and 1-[(2 E, 4 E, 9 E )-10-(3, 4-Methylenedioxyphenyl)-2, 4, 9-undecatrienoyl]pyrrolidine (4 ). Their structures were elucidated by extensive spectroscopic analyses, including 1D, 2D NMR and HR-ESI-MS, and by comparison with the literature. Compounds (2 –4 ) were isolated from Piper terminaliflorum Tseng for the first time. All isolated compounds (1 –4 ) were evaluated for their cytotoxic activities against five human cancer cell lines (including A-549, SMMC-7721, HL-60, MCF-7 and SW-480). Abstract :