Enhanced surface acoustic wave cell sorting by 3D microfluidic-chip design. Issue 23 (10th October 2017)

• Record Type: Journal Article
• Authors: Ung, W. L.; Mutafopulos, K.; Spink, P.; Rambach, R. W.; Franke, T.; Weitz, D. A.
• Is Part Of: Lab on a chip. Volume 17:Issue 23(2017)
• Page Start: 4059
• Page End: 4069
• Publication Date: 2017-10-10
• Subjects: Miniature electronic equipment -- Periodicals; Combinatorial chemistry -- Periodicals; Biotechnology -- Periodicals; 543.0813
• DOI: 10.1039/c7lc00715a
• Languages: English
• ISSNs: 1473-0197

Abstract

Abstract : We demonstrate an acoustic wave driven microfluidic cell sorter that combines advantages of multilayer device fabrication with planar surface acoustic wave excitation. Abstract : We demonstrate an acoustic wave driven microfluidic cell sorter that combines advantages of multilayer device fabrication with planar surface acoustic wave excitation. We harness the strong vertical component of the refracted acoustic wave to enhance cell actuation by using an asymmetric flow field to increase cell deflection. Precise control of the 3-dimensional flow is realized by topographical structures implemented on the top of the microchannel. We experimentally quantify the effect of the structure dimensions and acoustic parameter. The design attains cell sorting rates and purities approaching those of state of the art fluorescence-activated cell sorters with all the advantages of microfluidic cell sorting.