Highly efficient and versatile synthesis of α, α-difluoro-γ-lactams via aminodifluoroalkylation of alkenes. Issue 12 (12th September 2017)

• Record Type: Journal Article
• Authors: Chen, Hongtai; Wang, Xiaoyang; Guo, Minjie; Zhao, Wentao; Tang, Xiangyang; Wang, Guangwei
• Is Part Of: Organic chemistry frontiers. Volume 4:Issue 12(2017)
• Page Start: 2403
• Page End: 2407
• Publication Date: 2017-09-12
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c7qo00611j
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : An efficient approach to α, α-difluoro-γ-lactam derivatives was developed using a copper/amine catalyst via a tandem radical cyclization pathway. Abstract : A novel method for the synthesis of α, α-difluoro-γ-lactam derivatives has been developed using a copper/amine catalyst via a tandem radical cyclization pathway. This protocol provides a convenient and straightforward strategy for the rapid construction of various 3, 3-difluoro-γ-lactam moieties from easily available alkenes and N -aryl bromodifluoroacetamide as starting materials under mild reaction conditions.