Integrated microHall magnetometer to measure the magnetic properties of nanoparticles. Issue 23 (25th October 2017)

• Record Type: Journal Article
• Authors: Min, Changwook; Park, Jongmin; Mun, Jae Kyoung; Lim, Yongjun; Min, Jouha; Lim, Jong-Won; Kang, Dong-Min; Ahn, Ho-Kyun; Shin, Tae-Hyun; Cheon, Jinwoo; Lee, Hae-Seung; Weissleder, Ralph; Castro, Cesar M.; Lee, Hakho
• Is Part Of: Lab on a chip. Volume 17:Issue 23(2017)
• Page Start: 4000
• Page End: 4007
• Publication Date: 2017-10-25
• Subjects: Miniature electronic equipment -- Periodicals; Combinatorial chemistry -- Periodicals; Biotechnology -- Periodicals; 543.0813
• DOI: 10.1039/c7lc00934h
• Languages: English
• ISSNs: 1473-0197

Abstract

Abstract : We developed an integrated Hall magnetometer to measure magnetic properties in small sample volumes. Abstract : Magnetic nanoparticles (MNPs) are widely used in biomedical and clinical applications, including medical imaging, therapeutics, and biological sample processing. Rapid characterization of MNPs, notably their magnetic moments, should facilitate optimization of particle synthesis and accelerate assay development. Here, we report a compact and low-cost magnetometer for fast, on-site MNP characterization. Termed integrated microHall magnetometer (iHM), our device was fabricated using standard semiconductor processes: an array of Hall sensors, transistor switches, and amplifiers were integrated into a single chip, thus improving the detection sensitivity and facilitating chip operation. By applying the iHM, we demonstrate versatile magnetic assays. We measured the magnetic susceptibility and moments of MNPs using small sample amounts (∼10 pL), identified different MNP compositions in mixtures, and detected MNP-labeled single cells.