An expedient and novel strategy for reductive amination by employing H2O as both a hydrogen source and solvent via B2(OH)4/H2O systems. Issue 12 (10th October 2017)

• Record Type: Journal Article
• Authors: Wei, Yahui; Zhao, Cong; Xuan, Qingqing; Song, Qiuling
• Is Part Of: Organic chemistry frontiers. Volume 4:Issue 12(2017)
• Page Start: 2291
• Page End: 2295
• Publication Date: 2017-10-10
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c7qo00769h
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : An efficient, convenient and mild Ru-catalyzed reductive amination reaction was developed by employing H2 O as both hydrogen source and solvent via B2 (OH)4 /H2 O systems. α-Deuterated amines were also obtained expediently by employing D2 O in our catalytic systems. Abstract : An efficient, convenient and mild Ru-catalyzed reductive amination reaction was developed by employing H2 O as both hydrogen source and solvent via B2 (OH)4 /H2 O systems. The reaction proceeded smoothly under air at ambient temperature and exhibited excellent chemoselectivities toward unsaturated and heteroaromatic as well as aliphatic aldehydes. Interestingly, α-deuterated amines were also obtained expediently by employing D2 O in our catalytic systems.