Membrane environment drives cytochrome P450's spin transition and its interaction with cytochrome b5. Issue 95 (16th November 2017)
- Record Type:
- Journal Article
- Title:
- Membrane environment drives cytochrome P450's spin transition and its interaction with cytochrome b5. Issue 95 (16th November 2017)
- Main Title:
- Membrane environment drives cytochrome P450's spin transition and its interaction with cytochrome b5
- Authors:
- Ravula, Thirupathi
Barnaba, Carlo
Mahajan, Mukesh
Anantharamaiah, G. M.
Im, Sang-Choul
Waskell, Lucy
Ramamoorthy, Ayyalusamy - Abstract:
- Abstract : Cytochrome P450′s membrane interaction alters its spin equilibrium which is accompanied by a stronger affinity for cytochrome b 5 . Abstract : Heme's spin-multiplicity is key in determining the enzymatic function of cytochrome P450 (cytP450). The origin of the low-spin state in ferric P450 is still under debate. Here, we report the first experimental demonstration of P450's membrane interaction altering its spin equilibrium which is accompanied by a stronger affinity for cytochrome b 5 . These results highlight the importance of lipid membrane for the function of P450.
- Is Part Of:
- Chemical communications. Volume 53:Issue 95(2017)
- Journal:
- Chemical communications
- Issue:
- Volume 53:Issue 95(2017)
- Issue Display:
- Volume 53, Issue 95 (2017)
- Year:
- 2017
- Volume:
- 53
- Issue:
- 95
- Issue Sort Value:
- 2017-0053-0095-0000
- Page Start:
- 12798
- Page End:
- 12801
- Publication Date:
- 2017-11-16
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c7cc07520k ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 5389.xml