Diagnosis and treatment of depression and cognitive impairment in late life. (5th February 2015)

• Record Type: Journal Article
• Authors: Morimoto, Sarah Shizuko; Kanellopoulos, Dora; Manning, Kevin J.; Alexopoulos, George S.
• Other Names: Fink Matthew E. guestEditor.; Barchas Jack D. guestEditor.; Sheikh Javaid I. guestEditor.
• Is Part Of: Annals of the New York Academy of Sciences. Volume 1345(2015)
• Page Start: 36
• Page End: 46
• Publication Date: 2015-02-05
• Subjects: geriatric depression -- cognitive impairment -- older adults -- cognitive control -- psychotherapy -- antidepressants; Medical sciences -- Periodicals; Medicine -- Periodicals; Science -- Periodicals; 610
• DOI: 10.1111/nyas.12669
• Languages: English
• ISSNs: 0077-8923

Abstract

Abstract : Cognitive impairment in late‐life depression is prevalent, disabling, and heterogeneous. Although mild cognitive impairment in depression does not usually progress to dementia, accurate assessment of cognition is vital to prognosis and treatment planning. For example, executive dysfunction often accompanies late‐life depression, influences performance across cognitive domains, and is associated with poor antidepressant treatment outcomes. Here, we review how assessment can capture dysfunction across cognitive domains and discuss cognitive trajectories frequently observed in late‐life depression in the context of the neurobiology of this disorder. We also review the efficacy of a sample of interventions tailored to specific cognitive profiles.