ASK family in cardiovascular biology and medicine. (December 2017)

• Record Type: Journal Article
• Authors: Liu, Tingting; Zhou, Huanjiao Jenny; Min, Wang
• Is Part Of: Advances in biological regulation. Volume 66(2018)
• Page Start: 54
• Page End: 62
• Publication Date: 2017-12
• Subjects: Cellular control mechanisms -- Periodicals; Biological control systems -- Periodicals; Molecular biology -- Periodicals; Periodicals; 571.74
• DOI: 10.1016/j.jbior.2017.10.011
• Languages: English
• ISSNs: 2212-4926

Abstract

Abstract: Cardiovascular disease is a major cause of death worldwide. Mitogen-activated protein kinase (MAPK) signal cascades signaling pathways play crucial roles in cardiovascular pathophysiology. Apoptosis signal-regulating kinase (ASK) family members ASK1, ASK2 and ASK3 are the key molecules in MAPK signal cascades and are activated by various stresses. ASK1 is the most extensively studied MAPKKK and is involved in regulation of the cellular functions such as cell survival, proliferation, inflammation and apoptosis. The current review focuses on the relationship between ASK1 and cardiovascular disease, while exploring the novel therapeutic strategies for cardiovascular disease involved in the ASK1 signal pathway.