Modulation of antigen presentation by intracellular trafficking. (June 2015)

• Record Type: Journal Article
• Authors: Mintern, Justine D; Macri, Christophe; Villadangos, Jose A
• Is Part Of: Current opinion in immunology. Volume 34(2015)
• Page Start: 16
• Page End: 21
• Publication Date: 2015-06
• Subjects: Immunology -- Periodicals; Allergy -- Periodicals; Immunology -- Abstracts -- Periodicals; Allergy -- Abstracts -- Periodicals; 616.079
• DOI: 10.1016/j.coi.2014.12.006
• Languages: English
• ISSNs: 0952-7915

Abstract

Highlights: Antigen must access specialised compartments for MHC I and/or MHC II presentation. Antigen receptor targeting provides insight into trafficking routes for MHC I cross-presentation. Autophagy contributes to MHC I cross-presentation and cytosolic MHC II presentation. Specific types of antigen are trafficked differently for effective presentation. Abstract : Processing and loading of antigen into major histocompatibility complex molecules (MHC) occurs in specific intracellular compartments. Accessing MHC loading compartments requires trafficking via specific pathways, some of which have yet to be fully characterized. For MHC I, cross-presentation involves antigen trafficking to a specialised compartment. We review the features of this compartment and how it is accessed by different mechanisms of antigen capture and internalization. We also summarize advances in understanding how antigen efficiently accesses the MHC II loading compartment, with particular focus on the role of autophagy. Understanding the mechanisms that control how antigen is trafficked to specific compartments for loading and presentation is crucial if these pathways are to be manipulated more effectively in settings of vaccination.