Water-acetic acid mediated an efficient and eco-friendly protocol for the one-pot synthesis of bis-isoxazolyl amino dihydro-1H-indol-4(5H)-ones under mild reaction conditions. Issue 51 (20th December 2017)

• Record Type: Journal Article
• Authors: Nagi Reddy, Modugu; Praveen Kumar, Pittala
• Is Part Of: Tetrahedron letters. Volume 58:Issue 51(2017)
• Page Start: 4790
• Page End: 4795
• Publication Date: 2017-12-20
• Subjects: Bis-isoxazolyl amino dihydro-1H-indol-4(5H)-one -- One-pot synthesis -- Water -- AcOH -- Green chemistry; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2017.11.027
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: We have synthesized bis-isoxazolyl amino dihydro-1 H -indol-4(5 H )-ones by a one-pot three-component reaction. Transition metal free synthesis. Wide substrate scope, excellent functional group tolerance. Excellent yields. Abstract: A cost-effective and eco-friendly straightforward synthesis of new bis-isoxazolyl amino dihydro-1 H -indol-4(5 H )-ones is successfully achieved via one-pot three-component reaction of N -isoxazolyl enaminone, aryl glyoxal monohydrates and 4-amino-3-methyl-5-styrylisoxazoles by using water as a reaction medium and acetic acid (AcOH) as cheap and green promoter. The protocol proves to be an efficient and environmentally benign in terms of high yields, low reaction time, operational simplicity, metal-free and wide substrates scope. Most important of all, this reaction process is green.