Fusobacterium nucleatum detected simultaneously in a pyogenic liver abscess and advanced sigmoid colon cancer. (December 2017)

• Record Type: Journal Article
• Authors: Shigefuku, Ryuta; Watanabe, Tsunamasa; Kanno, Yuki; Ikeda, Hiroki; Nakano, Hiroyasu; Hattori, Nobuhiro; Matsunaga, Kotaro; Matsumoto, Nobuyuki; Kanno, Shin-ichi; Nosho, Katsuhiko; Hachiya, Atsuko; Iwatani, Yasumasa; Matsumori, Tomoko; Tsukikawa, Satoshi; Makizumi, Ryoji; Otsubo, Takehito; Yamamoto, Hiroyuki; Itoh, Fumio
• Is Part Of: Anaerobe. Volume 48(2017)
• Page Start: 144
• Page End: 146
• Publication Date: 2017-12
• Subjects: Fusobacterium nucleatum -- Pyogenic liver abscess -- Colon cancer -- Metagenome analysis -- Microbial FISH; Anaerobic infections -- Periodicals; Anaerobic bacteria -- Periodicals; Bacterial diseases -- Periodicals; Computer network resources; Anaerobic protozoa -- Periodicals; 579.3
• DOI: 10.1016/j.anaerobe.2017.08.010
• Languages: English
• ISSNs: 1075-9964

Abstract

Abstract: Fusobacterium nucleatum is an invasive, adherent, and pro-inflammatory anaerobic bacterium involved in various infections and colorectal cancer. We report a case with pyogenic liver abscess, diagnosed with advanced sigmoid colon cancer, in whom F. nucleatum was simultaneously detected. In this patient, F. nucleatum was systematically analyzed using the molecular biological techniques of metagenome analysis, conventional PCR, and microbial fluorescence in situ hybridization. Highlights: F. nucleatum was detected in a patient with pyogenic liver abscess and colon cancer. FISH analysis detected invasive F. nucleatum in cancer but not in normal tissue. The connection between PLA and colon cancer in regard to F. nucleatum was suggested.