Physical capability predicts mortality in late mid-life as well as in old age: Findings from a large British cohort study. (January 2018)

• Record Type: Journal Article
• Authors: Keevil, Victoria L.; Luben, Robert; Hayat, Shabina; Sayer, Avan A.; Wareham, Nicholas J.; Khaw, Kay-Tee
• Is Part Of: Archives of gerontology and geriatrics. Volume 74(2018)
• Page Start: 77
• Page End: 82
• Publication Date: 2018-01
• Subjects: Physical performance -- Mortality -- Epidemiology -- Mid-late life; Aging -- Periodicals; Geriatrics -- Periodicals; Gerontology -- Periodicals; Electronic journals; 305.26
• DOI: 10.1016/j.archger.2017.10.001
• Languages: English
• ISSNs: 0167-4943

Abstract

Graphical abstract: Highlights: Physical capability predicts mortality in community-based British men and women. Mortality associations are similar in mid- (48–69 years) and late-life (70+ years). Co-morbidity burden and shared risk factors did not explain associations. Biological mechanisms linking physical capability and mortality could be explored. Abstract: Introduction: Low physical capability predicts mortality, perhaps by association with co-morbidity. However, few studies include participants <70 years old with lower co-morbidity burdens compared to older adults. We examined relationships between usual walking speed (UWS), timed chair stands speed, grip strength, standing balance and all-cause mortality in 8477 participants aged 48–92 years enrolled in the European Prospective Investigation of Cancer-Norfolk study. Methods: Participants (55.1% female) were followed up for 6.0 years (inter-quartile range 4.6, 7.5). Associations were examined using Cox proportional hazards regression by age-group (<70 years versus ≥70 years) and then in the whole cohort adjusted for age, sex, anthropometry, history of diabetes/stroke/myocardial infarction/cancer, smoking, alcohol intake, socioeconomic status, television viewing time and physical activity. Results: Age and sex adjusted associations were similar in younger and older participants (Pinteraction all >0.05) and those with lower physical capability had higher mortality risk. For example, in those <70 years old hazard ratios (95% confidence interval) for mortality in the third, second and lowest sex-specific quartiles of UWS compared to the highest were 1.21 (0.75, 1.96), 2.11 (1.35, 3.28) and 2.91 (1.84, 4.62) and in participants ≥70 years old were 1.19 (0.73, 1.95), 2.09 (1.35, 3.24) and 2.64 (1.73, 4.02) respectively. In the whole cohort, strong associations between all physical capability tests and mortality persisted after multivariable adjustment and after excluding participants with co-morbidity. Conclusions: Physical capability was independently predictive of future mortality risk with similar associations in late mid-life, when co-morbidity burden is lower, as at older age.