Establishment of valnemulin susceptibility breakpoint against Clostridium perfringens in rabbits. (December 2017)

• Record Type: Journal Article
• Authors: Tao, Meng-Ting; Zhou, Yu-Feng; Sun, Jian; Liu, Ya-Hong; Liao, Xiao-Ping
• Is Part Of: Anaerobe. Volume 48(2017)
• Page Start: 118
• Page End: 120
• Publication Date: 2017-12
• Subjects: Valnemulin -- Susceptibility breakpoint -- Cutoff -- C. perfringens; Anaerobic infections -- Periodicals; Anaerobic bacteria -- Periodicals; Bacterial diseases -- Periodicals; Computer network resources; Anaerobic protozoa -- Periodicals; 579.3
• DOI: 10.1016/j.anaerobe.2017.08.006
• Languages: English
• ISSNs: 1075-9964

Abstract

Abstract: Susceptibility breakpoints provide fundamental information for rational administration of antibiotics. The present investigation reports the first valnemulin susceptibility breakpoint (MIC<0.25 μg/mL) against Clostridium perfringens infections in rabbits based on the wild-type cutoff (COWT ) and the pharmacokinetics/pharmacodynamic (PK/PD) cutoff (COPD ). The established susceptibility breakpoint of valnemulin might be useful in resistance surveillance of pleuromutilins and development of clinical breakpoints. Highlights: We summarized the MIC distribution of valnemulin against rabbit C. perfringens. Pharmacokinetics of valnemulin in rabbit intestinal tract was reported. We established the COWT and COPD levels for valnemulin against C. perfringens. The established breakpoint will be useful in pleuromutilin resistance surveillance.