Formation of the Protein Corona: The Interface between Nanoparticles and the Immune System. (December 2017)

• Record Type: Journal Article
• Authors: Barbero, Francesco; Russo, Lorenzo; Vitali, Michele; Piella, Jordi; Salvo, Ignacio; Borrajo, Mireya L.; Busquets-Fité, Marti; Grandori, Rita; Bastús, Neus G.; Casals, Eudald; Puntes, Victor
• Is Part Of: Seminars in immunology. Volume 34(2017)
• Page Start: 52
• Page End: 60
• Publication Date: 2017-12
• Subjects: Nanoparticle-Protein Corona -- Inorganic Nanoparticles -- Immune Response -- Homo and Hetero-aggregation -- Protein Corona Characterization -- Vroman Effect; Immunology -- Periodicals; Allergy and Immunology -- Periodicals; Immunity -- Periodicals; Immunologie -- Périodiques; Electronic journals; 616.079
• DOI: 10.1016/j.smim.2017.10.001
• Languages: English
• ISSNs: 1044-5323

Abstract

Abstract: The interaction of inorganic nanoparticles and many biological fluids often withstands the formation of a Protein Corona enveloping the nanoparticle. This Protein Corona provides the biological identity to the nanoparticle that the immune system will detect. The formation of this Protein Corona depends not only on the composition of the nanoparticle, its size, shape, surface state and exposure time, but also on the type of media, nanoparticle to protein ratio and the presence of ions and other molecular species that interfere in the interaction between proteins and nanoparticles. This has important implications on immune safety, biocompatibility and the use of nanoparticles in medicine.