RanBPM: a potential therapeutic target for modulating diverse physiological disorders. Issue 12 (December 2017)

• Record Type: Journal Article
• Authors: Das, Soumyadip; Suresh, Bharathi; Kim, Hyongbum (Henry); Ramakrishna, Suresh
• Is Part Of: Drug discovery today. Volume 22:Issue 12(2017)
• Page Start: 1816
• Page End: 1824
• Publication Date: 2017-12
• Subjects: Drugs -- Design -- Periodicals; Drugs -- Research -- Periodicals; 615.1
• DOI: 10.1016/j.drudis.2017.08.005
• Languages: English
• ISSNs: 1359-6446

Abstract

Highlights: The diverse biological functions of RanBPM and its interacting partners are reviewed. RanBPM is linked to various proteins and cellular pathways leading to modulation of numerous physiological disorders. RanBPM can be a potential therapeutic target for dreadful diseases. Abstract : The Ran-binding protein microtubule-organizing center (RanBPM) is a highly conserved nucleocytoplasmic protein involved in a variety of intracellular signaling pathways that control diverse cellular functions. RanBPM interacts with proteins that are linked to various diseases, including Alzheimer's disease (AD), schizophrenia (SCZ), and cancer. In this article, we define the characteristics of the scaffolding protein RanBPM and focus on its interaction partners in diverse physiological disorders, such as neurological diseases, fertility disorders, and cancer.