Serum Clara cell protein and atopic phenotype in children up to 2 years of age. Issue 6 (1st February 2017)

• Record Type: Journal Article
• Authors: Ilic, Nevenka; Mihailovic, Natasa
• Is Part Of: Journal of clinical laboratory analysis. Volume 31:Issue 6(2017:Nov.)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-02-01
• Subjects: allergy -- asthma -- biomarkers -- Clara cell protein; Diagnosis, Laboratory -- Periodicals; Medical laboratory technology -- Periodicals; 616
• DOI: 10.1002/jcla.22151
• Languages: English
• ISSNs: 0887-8013

Abstract

Abstract : Background: Low value of serum Clara cell protein (CC16) is associated with bronchial hyperreactivity in children. Objective: To evaluate the serum CC16 in relation to atopy and previously manifested LRTD. Methods: In the population of 163 healthy 5‐ to 24‐month‐old children, atopy was determined by Phadiatop‐infant (serum‐specific IgE≥0.35 kUA/L), serum CC16 by ELISA, while data on previously manifested low respiratory tract diseases (LRTD) were collected from the Health Care Center database. Results: In atopic children, serum CC16 negatively correlated with age ( r −.281, P =.041, n=53), while in nonatopic children, this correlation was positive ( r .200, P =.036, n=110). Atopic ≥8‐month‐old children with previously manifested LRTD had lower level of CC16 (3.07 ng/mL) in relation to atopic children without LRTD at the same age (6.51 ng/mL), P =.029 (value of serum CC16≥4.8 ng/mL indicates atopic phenotype without LRTD 75% sensitivity, 87.5% specificity). In 8‐ to 24‐month‐old children with previously manifested pneumonia, serum CC16 was lower in atopic (2.9 ng/mL) in relation to nonatopic children (3.7 ng/mL), P =.029 (serum CC16 ≤3.4 ng/mL indicating atopy in the group of children with pneumonia, sensitivity 100%, and specificity 77%). Atopic 8‐ to 24‐month‐old children with previously manifested pneumonia had lower CC16 in relation to other atopic children in this age ( P =.021) (for cutoff CC16≤3.4 ng/mL sensitivity 100%, specificity 77%), and also often chronic wheezing (atopic with pneumonia 83.3%, n=5/6 vs atopic without pneumonia 21.4%, n=3/14), P =.018. Conclusion: Low serum CC16 is associated with previously expressed pneumonia and chronic wheezing in atopic children.