Isoprostanes, neuroprostanes and phytoprostanes: An overview of 25 years of research in chemistry and biology. (October 2017)

• Record Type: Journal Article
• Authors: Galano, Jean-Marie; Lee, Yiu Yiu; Oger, Camille; Vigor, Claire; Vercauteren, Joseph; Durand, Thierry; Giera, Martin; Lee, Jetty Chung-Yung
• Is Part Of: Progress in lipid research. Volume 68(2017:Oct.)
• Page Start: 83
• Page End: 108
• Publication Date: 2017-10
• Subjects: Isoprostanes -- Neuroprostanes -- Phytoprostanes -- Lipid Peroxidation -- Polyunsaturated fatty acids; AA Arachidonic acid -- AD Alzheimer's disease -- AdA Adrenic acid -- ALA α-Linolenic acid -- APCI Atmospheric pressure chemical ionization -- BHT Butylated hydroxytoluene -- BSTFA bis-(trimethylsilyl)trifluoroacetamide -- CCl4 Carbon tetrachloride -- DHA Docosahexaenoic acid -- Dihomo-IsoP Dihomo-isoprostane -- DTPA Diethylene tri-amine pentaacetic acid -- ECNI Electron-capture negative ionization -- ELISA Enzyme-linked immunosorbent assay -- EPA Eicosapentaenoic acid -- ESI Electrospray ionization -- GC-MS Gas chromatography mass spectrometry -- GSH Glutathione -- IL Interleukin -- IsoP Isoprostane -- Keap1 Kelch-like ECH-associated protein 1 -- LC-MS Liquid chromatography mass spectrometry -- LPS Lipopolysaccharides -- MRM Multiple-reaction monitoring -- MS/MS Tandem mass spectrometry -- MTBE Methyl tert-butyl ether -- NeuroP Neuroprostane -- NF-κB Nuclear factor-kappaB -- NPD1 Neuroprotectin D1 -- Nrf2 Nuclear factor erythroid 2-related factor 2 -- PDX Protectin DX -- PεCL Poly-ε-caprolactone -- PFBBr Pentafluorobenzyl bromide -- PG Prostagladin -- PhytoP Phytoprostane -- PPARγ Peroxisome proliferator-activated receptor gamma -- PUFA Polyunsaturated fatty acid -- RIA Radioimmunoassay -- ROS Reactive oxygen species -- RTT Rett syndrome -- SIM Selected-ion monitoring -- SPE Solid phase extraction -- TLC Thin layer chromatography -- TPP Triphenylphosphine -- TPR Thromboxane receptor; Lipids -- Periodicals; Lipids -- Periodicals; Lipides -- Périodiques; Lipiden; 572.57
• DOI: 10.1016/j.plipres.2017.09.004
• Languages: English
• ISSNs: 0163-7827

Abstract

Abstract: Since the beginning of the 1990's diverse types of metabolites originating from polyunsaturated fatty acids, formed under autooxidative conditions were discovered. Known as prostaglandin isomers (or isoprostanoids) originating from arachidonic acid, neuroprostanes from docosahexaenoic acid, and phytoprostanes from α-linolenic acid proved to be prevalent in biology. The syntheses of these compounds by organic chemists and the development of sophisticated mass spectrometry methods has boosted our understanding of the isoprostanoid biology. In recent years, it has become accepted that these molecules not only serve as markers of oxidative damage but also exhibit a wide range of bioactivities. In addition, isoprostanoids have emerged as indicators of oxidative stress in humans and their environment. This review explores in detail the isoprostanoid chemistry and biology that has been achieved in the past three decades.