Association between radiography-based subchondral bone structure and MRI-based cartilage composition in postmenopausal women with mild osteoarthritis. Issue 12 (December 2017)

• Record Type: Journal Article
• Authors: Hirvasniemi, J.; Thevenot, J.; Multanen, J.; Haapea, M.; Heinonen, A.; Nieminen, M.T.; Saarakkala, S.
• Is Part Of: Osteoarthritis and cartilage. Volume 25:Issue 12(2017)
• Page Start: 2039
• Page End: 2046
• Publication Date: 2017-12
• Subjects: Radiography -- MRI -- Osteoarthritis -- Bone structure -- Cartilage composition -- Knee; Osteoarthritis -- Periodicals; Cartilage -- Periodicals; Osteoarthritis -- Periodicals; Cartilage -- Periodicals; Arthrose -- Périodiques; Articulations -- Maladies -- Périodiques; 616.7223005
• DOI: 10.1016/j.joca.2017.09.008
• Languages: English
• ISSNs: 1063-4584

Abstract

Summary: Objective: Our aim was to investigate the relation between radiograph-based subchondral bone structure and cartilage composition assessed with delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC) and T 2 relaxation time. Design: Ninety-three postmenopausal women (Kellgren–Lawrence grade 0: n = 13, 1: n = 26, 2: n = 54) were included. Radiograph-based bone structure was assessed using entropy of the Laplacian-based image ( E Lap ) and local binary patterns ( E LBP ), homogeneity indices of the local angles (HIAngles, mean, HIAngles, Perp, HIAngles, Paral ), and horizontal (FDHor ) and vertical fractal dimensions (FDVer ). Mean dGEMRIC index and T 2 relaxation time of tibial cartilage were calculated to estimate cartilage composition. Results: HIAngles, mean ( r s = −0.22) and HIAngles, Paral ( r s = −0.24) in medial subchondral bone were related ( P < 0.05) to dGEMRIC index of the medial tibial cartilage. E Lap ( r s = −0.23), FDHor, 0.34 mm ( r = 0.21) and FDVer, 0.68 mm ( r = 0.24) in medial subchondral bone were related ( P < 0.05) to T 2 relaxation time values of the medial tibial cartilage. FDHor at different scales in lateral subchondral bone were related ( P < 0.01) to dGEMRIC index ( r = 0.29–0.41) and T 2 values of lateral tibial cartilage ( r = −0.28 to −0.36). FDVer at larger scales were related ( P < 0.05) to dGEMRIC index ( r = 0.24–0.25) and T 2 values of lateral tibial cartilage ( r = −0.21). HIAngles, Paral ( r = −0.25) and FDVer, 0.68 mm ( r s = 0.22) in the lateral tibial trabecular bone were related ( P < 0.05) to dGEMRIC index of the lateral tibial cartilage. Conclusion: Our results support the presumption that several tissues are affected in the early osteoarthritis (OA). Furthermore, they indicate that the detailed analysis of radiographs may serve as a complementary imaging tool for OA studies.