A Platinum(II)‐based Photosensitive Tripod as an Effective Photodynamic Anticancer Agent through DNA Damage. Issue 65 (26th October 2017)

• Record Type: Journal Article
• Authors: Zhong, Yi‐Fang; Zhang, Hang; Liu, Wen‐Ting; Zheng, Xiao‐Hui; Zhou, Yi‐Wei; Cao, Qian; Shen, Yong; Zhao, Yong; Qin, Peter Z.; Ji, Liang‐Nian; Mao, Zong‐Wan
• Is Part Of: Chemistry. Volume 23:Issue 65(2017)
• Page Start: 16442
• Page End: 16446
• Publication Date: 2017-10-26
• Subjects: apoptosis -- dna damage -- photodynamic therapy -- platinum; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201703598
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: Herein, two photosensitive platinum(II)‐based tripods were designed and synthesized. Notably, complex 1 ({[Pt(dien)]3 L }(NO3 )6, L =tri(4‐pyridylphenyl)amine and dien=diethylenetriamine), which mainly accumulated in the cell nucleus, exhibited very low cytotoxicity in the absence of light irradiation, but displayed a remarkable increase in cytotoxicity upon visible light irradiation. Mechanistic investigations revealed that the tripod interacted with DNA in the nucleus, induced ROS generation upon light irradiation, and consequently elicited rapid DNA damage response; thereby triggering cancer cell apoptosis. Abstract : An effective photodynamic anticancer agent : A platinum(II)‐based tripod was designed, synthesized, and shown to be a highly effective photodynamic anticancer agent. Mechanistic investigations revealed that the tripod interacted with DNA in the nucleus, induced ROS generation upon light irradiation, and consequently elicited rapid DNA damage response; thereby triggering cancer cell apoptosis.