Brain lesions affecting gait recovery in stroke patients. Issue 11 (25th October 2017)

• Record Type: Journal Article
• Authors: Lee, Kyoung Bo; Kim, Joon Sung; Hong, Bo Young; Sul, Bomi; Song, Seojin; Sung, Won Jin; Hwang, Byong Yong; Lim, Seong Hoon
• Is Part Of: Brain and behavior. Volume 7:Issue 11(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-10-25
• Subjects: brain lesion -- gait -- lesion symptom mapping -- recovery -- stroke; Neurology -- Periodicals; Neurosciences -- Periodicals; Psychology -- Periodicals; Psychiatry -- Periodicals; 616.8005
• DOI: 10.1002/brb3.868
• Languages: English
• ISSNs: 2162-3279

Abstract

Abstract: Objectives: Gait recovery is an important goal in stroke patients. Several studies have sought to uncover relationships between specific brain lesions and the recovery of gait, but the effects of specific brain lesions on gait remain unclear. Thus, we investigated the effects of stroke lesions on gait recovery in stroke patients. Materials and Methods: In total, 30 subjects with stroke were assessed in a retrograde longitudinal observational study. To assess gait function, the functional ambulation category (FAC) was tested four times: initially (within 2 weeks) and 1, 3, and 6 months after the onset of the stroke. Brain lesions were analyzed via overlap, subtraction, and voxel‐based lesion symptom mapping (VLSM). Results: Ambulation with FAC improved significantly with time. Subtraction analysis showed that involvement of the corona radiata, internal capsule, globus pallidus, and putamen were associated with poor recovery of gait throughout 6 months after onset. The caudate nucleus did influence poor recovery of gait at 6 months after onset. VLSM revealed that corona radiata, internal capsule, globus pallidus, putamen and cingulum were related with poor recovery of gait at 3 months after onset. Corona radiata, internal capsule, globus pallidus, putamen, primary motor cortex, and caudate nucleus were related with poor recovery of gait at 6 months after onset. Conclusion: Results identified several important brain lesions for gait recovery in patients with stroke. These results may be useful for planning rehabilitation strategies for gait and understanding the prognosis of gait in stroke patients. Abstract : Gait recovery is an important goal in stroke patients. Corona radiata, internal capsule, and striatum were associated with poor recovery of gait. Caudate nucleus and putamen have an important role in the recovery of the gait in patients with stroke.