Applications of Lawesson's reagent in the synthesis of naturally occurring steroids and terpenoids. Issue 11 (2nd November 2017)

• Record Type: Journal Article
• Authors: Saeed, Aamer; Mehfooz, Haroon; Larik, Fayaz Ali; Faisal, Muhammad; Channar, Pervaiz Ali
• Is Part Of: Journal of Asian natural products research. Volume 19:Issue 11(2017)
• Page Start: 1114
• Page End: 1123
• Publication Date: 2017-11-02
• Subjects: Lawesson's reagent -- steroids -- terpenoids -- thionation; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2017.1295229
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Steroids and terpenoids are among the most biologically significant classes of natural products possessing a variety of biological activities. The replacement of one or more oxygen atoms in a steroid or terpenoid molecule by a heteroatom affects the chemical properties of that particular steroid or terpenoid, and that replacement often results in alterations of its biological properties, which is sometimes valuable. One possible modification is the thionation that could have some influence on such activity. Among the various thionating reagents, Lawesson's reagent was found to be most suitable and showed versatile properties, including chemoselectivity and functional group tolerance. In this review, we present the role of Lawesson's reagent in the synthesis of thioanalogues of natural steroids and terpenoids. Abstract :