Association between triglyceride/high-density lipoprotein ratio and hearing impairment in a Korean population. Issue 8 (17th November 2017)

• Record Type: Journal Article
• Authors: Jung, Da Jung; Do, Jun Young; Cho, Kyu Hyang; Kim, A. Young; Kang, Seok Hui
• Is Part Of: Postgraduate medicine. Volume 129:Issue 8(2017)
• Page Start: 943
• Page End: 948
• Publication Date: 2017-11-17
• Subjects: Triglyceride -- high-density lipoprotein -- hearing loss -- insulin resistance; Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610.5
• DOI: 10.1080/00325481.2017.1381538
• Languages: English
• ISSNs: 0032-5481

Abstract

ABSTRACT: Objective : The aim of the present study was to evaluate the clinical association between triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio and hearing impairment in a Korean population. Patients and methods : This was a cross-sectional study (n = 18, 004). Participants were divided into 4 quartiles based on their TG/HDL-C ratio: first quartile (1Q), second quartile (2Q), third quartile (3Q), and fourth quartile (4Q). The threshold values at 0.5, 1, and 2 kHz were averaged to obtain the low- or mid-frequency pure-tone average (Low/Mid-Freq), and the values at 3, 4, and 6 kHz were averaged to obtain the high-frequency pure-tone average (High-Freq). The average hearing threshold (AHT) was calculated as the pure-tone average of the thresholds at 0.5, 1, 2, and 3 kHz. Hearing loss (HL) was defined as an AHT of >40 dB. Results : The Low/Mid-Freq, High-Freq, and AHT values were the highest among participants in 4Q than among those in the other quartiles. Compared with those in 1Q, 2Q, or 3Q, participants in 4Q exhibited a 1.32, 1.27, and 1.16-fold higher odds for HL, respectively. Partial correlation coefficients for TG/HDL-C ratio were 0.065 for Low/Mid-Freq, 0.041 for High-Freq, and 0.060 for AHT ( P < 0.001 for all). Linear regression analyses showed that β ± SE for TG/HDL-C ratio was 0.293 ± 0.038 on multivariate analysis. In addition, all subgroup analyses except diabetes participants showed statistically significant association between TG/HDL-C ratio and HL. Conclusion : High TG/HDL-C ratio was associated with hearing impairment in a Korean population.